| 10 mg多廿烷醇与等剂量阿托伐他汀在血脂异常患者中调脂疗效比较的荟萃分析 |
| 投稿时间：2016-06-06 修订日期：2016-10-13 点此下载全文 |
| 引用本文：应茵,陆绪亮,董威夷,宋洪涛.10 mg多廿烷醇与等剂量阿托伐他汀在血脂异常患者中调脂疗效比较的荟萃分析[J].药学实践杂志,2017,35(3):282~288 |
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| 中文摘要:目的 探讨比较10 mg多廿烷醇与等剂量阿托伐他汀在血脂异常患者中调脂的疗效。方法 检索维普网（VIP）、万方数据库、中国知网（CNKI）以及Cochrance图书馆、美国国立医学图书馆（PubMed）、科学引文索引数据库（Web of Science）、荷兰医学文摘（EMBASE）等数据库，查找10 mg多廿烷醇和10 mg阿托伐他汀的随机对照试验（RCT）和临床对照试验（CCT），使用Cochrance Handbook 5.1.0评价系统或Newcastle-Ottawa量表（NOS）进行质量评价，采用RevMan5.2软件对纳入研究中的相关数据进行统计学分析。结果 共纳入4篇RCT文献，受试者257例，其中10 mg多廿烷醇组130例，10 mg阿托伐他汀组127例。荟萃（Meta）分析结果显示，在降低总胆固醇（TC）[SMD=0.84，95%CI：（0.41，1.27），P=0.000 1]和低密度脂蛋白胆固醇（LDL-C）[SMD=0.68，95%CI：（0.28，1.09），P=0.001]方面，10 mg阿托伐他汀组均优于10 mg多廿烷醇组；在升高高密度脂蛋白胆固醇（HDL-C）[SMD=0.27，95%CI：（0.02，0.51），P=0.03]方面，10 mg多廿烷醇组优于10 mg阿托伐他汀组；在降低甘油三脂（TG）[SMD=0.10，95%CI：（-0.41，0.35），P=0.42]方面，两组无统计学差异。结论 在血脂异常患者调脂治疗时，10 mg阿托伐他汀的疗效更优于等剂量的多廿烷醇，在替换阿托伐他汀治疗时应考虑增加多廿烷醇给药剂量，以保证调脂疗效。本研究存在纳入研究少、样本量小等局限性，结论的可靠性仍需多中心、大样本的高质量RCT研究加以验证。 |
| 中文关键词:多廿烷醇 阿托伐他汀 等剂量 调脂疗效 荟萃分析 |
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| Meta-analysis of 10 mg policosanol versus an equal dose of atorvastatin on the lipid-lowering efficacy in patients with dyslipidemia |
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| Abstract:Objective To evaluate the lipid-lowering effect of 10 mg policosanol versus an equal dose of atorvastatinin patients with dyslipidemia. Method Databases such as VIP,Wanfang,CNKI,Cochrance Library,PubMed,Web of Science and EMBASE were searched for random control trials(RCT) and controlled clinical trials (CCT) of 10 mg policosanol versus an equal dose of atorvastatinin their lipid-lowering effects. The quality was assessed by Cochrance Handbook 5.1.0 or Newcastle-Ottawa scale (NOS).The study related data were analyzed statistically with RevMan 5.2 software.4 RCTs were selected. 257 patients were included in the trials. 130 cases were in 10 mg policosanol group and 127 cases belonged to 10 mg atorvastatin group. Results Results of Meta-analysis show that TC[SMD=0.84,95%CI(0.41,1.27),P=0.000 1] and LDL-C[SMD=0.68,95%CI(0.28,1.09),P=0.001] were reduced more effectively in 10 mg atorvastatin group than in 10 mg policosanol group.HDL-C[SMD=0.27,95%CI(0.02,0.51),P=0.03] was elevated more in 10 mg policosanol group than 10 mg atorvastatin group.Both groups showed no statistic difference(P=0.42) in TG [SMD=0.10,95% CI:(-0.41,0.35),P=0.42]. Conclusion The lipid-lowering efficacy of 10 mg atorvastatin is better than equal dose of policosanolin patients with dyslipidemia. Dose increase of policosanol should be considered to ensure the efficacy when policosanol was used tore place atorvastatin therapy. This study had some shortcomings, such as limited study numbers and small sample size. The reliability of this study should be verified from high-quality,multi-center RCTS with large samples. |
| keywords:policosanol atorvastatin equaldose lipid-lowering efficacy Meta-analysis |
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