| 辐射防护相关信号通路研究现状 |
| 投稿时间：2016-10-13 修订日期：2016-12-19 点此下载全文 |
| 引用本文：王静,章越凡,李铁军.辐射防护相关信号通路研究现状[J].药学实践杂志,2017,35(1):8~11 |
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| 基金项目:“重大新药创制”科技重大专项：军队特需药品发现技术平台（2011ZXJ09201-012） |
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| 中文摘要:人们在生活中接触到各种辐射，长期或者大剂量的辐射能够导致组织损伤，其机制通常与细胞凋亡、坏死、炎症等相关。目前关于辐射防护的研究越来越多，其中涉及多条通路，代表性的通路有：NFκB通路、MAPK通路、PI3K/Akt通路、p53通路以及STAT3通路。笔者综述了上述通路在辐射防护领域的作用与研究现状。 |
| 中文关键词:电离辐射 辐射防护 信号通路 |
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| Signaling pathways involved in radioprotection |
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| Abstract:People do have some risks of exposing to the radiation during their daily life.Longtime or megadose ionizing radiation can induce tissue damage, which is related to cell apoptosis, necrosis and inflammation, etc..Currently, more and more radio protective agents were developed and several signaling pathways were involved. NFκB, MAPK, PI3k/Akt, p53 and STAT3 signaling pathways were reviewed in this article. |
| keywords:ionizing radiation radioprotection signaling pathway |
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