| 依布硒的生理活性及合成方法研究进展 |
| 投稿时间：2016-03-08 修订日期：2016-06-20 点此下载全文 |
| 引用本文：刘晓盈,孙一鸣,赵宇亭,吴显东,马鹏程,杨超,郑灿辉.依布硒的生理活性及合成方法研究进展[J].药学实践杂志,2017,35(1):5~ |
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| 基金项目:第二军医大学大学生创新能力培养基金（MS2014059）资助 |
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| 中文摘要:有机硒类化合物是一类具有广泛生理活性的生物活性物质。依布硒是其代表化合物，它作为谷胱甘肽过氧化物酶的小分子模拟物可以被用于心脑血管疾病、炎症和噪声致听力损伤等多种疾病的治疗。笔者简要综述了依布硒的生理活性和合成方法的研究进展。 |
| 中文关键词:依布硒 有机硒类化合物 谷胱甘肽过氧化物酶 生理活性 合成方法 |
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| Progress on physiological activities and synthetic methods of ebselen |
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| Abstract:Organoselenium compounds are bioactive substances with extensive physiological activities. As a representative compound, ebselen could be used as mimics of glutathione peroxidase, and in the treatment of many diseases, such as cardiovascular and cerebrovascular diseases, inflammation and noise-induced hearing loss. the research progress in physiological activities and synthetic methods of ebselen were reviewed in this paper. |
| keywords:ebselen organoselenium compounds glutathione peroxidase physiological activities synthetic methods |
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