| 孤儿核受体NR4A1与动脉粥样硬化的研究进展 |
| 投稿时间：2016-01-28 修订日期：2016-04-22 点此下载全文 |
| 引用本文：干润,霍炎,黄金路,杨全军,郭澄.孤儿核受体NR4A1与动脉粥样硬化的研究进展[J].药学实践杂志,2016,34(4):292~296 |
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| 基金项目:国家自然科学基金（81503155）；上海市科委基金（14ZR1432200）；上海交通大学医工交叉项目（YG2014MS21） |
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| 中文摘要:孤儿核受体NR4A1是尚未发现特异性配体的转录因子之一，属于NR4A亚家族。早期研究发现，NR4A1可通过改变基因表达、翻译后修饰以及辅调蛋白间相互作用，调控细胞的增殖、凋亡、分化和应激反应。近年来研究发现其在动脉粥样硬化损伤部位表达异常，被认为是血管细胞功能紊乱过程中的关键调节基因。通过调控NR4A1基因的表达，可对平滑肌细胞的增殖和内皮细胞的激活产生重要影响，同时能够减少炎症反应、减少泡沫细胞的形成以及脂质沉积，抑制血管重塑，预防和阻止动脉粥样硬化的发生与发展。这些研究显示NR4A1可能成为研发预防和治疗动脉粥样硬化药物的新靶点。 |
| 中文关键词:孤儿核受体 NR4A1 动脉粥样硬化 血管细胞 |
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| Research progress on orphan nuclear receptor NR4A1 in atherosclerosis |
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| Abstract:Orphan nuclear receptor NR4A1 from the NR4A subfamily is one of the transcriptional factors that have not identified specific ligands. Previous studies have found that NR4A1 could regulate cell proliferation, apoptosis, differentiation and stress responses by changing gene expression, post-translational modification and interactions between coregulatory proteins. Recently, it has shown that NR4A1 has an abnormal expression in human atherosclerotic lesions and has been identified as a key regulator gene in vascular cells dysfunction. Regulating NR4A1 expression can have an important impact on the proliferation of smooth muscle cell and endothelial cell activation,meanwhile it could reduce inflammation,foam cell formation and lipid deposition,inhibit vascular remodeling,and prevent the development of atherosclerosis. These studies suggest that NR4A1 might be a novel target for drug development in prevention and treatment of atherosclerosis. |
| keywords:orphan nuclear receptor NR4A1 atherosclerosis vascular cells |
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