| 芍药苷胃漂浮片的制备 |
| 投稿时间：2015-02-08 修订日期：2015-12-02 点此下载全文 |
| 引用本文：贾家丽,黄月英,卞俊.芍药苷胃漂浮片的制备[J].药学实践杂志,2016,34(2):153~157 |
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| 中文摘要:目的 制备芍药苷胃漂浮片,优选芍药苷胃漂浮片的制备工艺。方法 采用湿法制粒压片制备芍药苷胃漂浮片,以漂浮性能和体外累积释放率为考查指标,采用单因素筛选及正交设计法,优化芍药苷胃漂浮片处方。结果 以HPMC K4M(20%)为骨架材料、NaHCO3(15%)为起泡剂、PVPP(7%)为释放促进剂、乳糖200为填充剂制得的胃漂浮片能立即起漂,持续漂浮12 h以上,累积释放率达90%以上。结论 优选的芍药苷胃漂浮片达到了持续漂浮及缓慢释放的要求,可操作性强。 |
| 中文关键词:芍药苷 胃漂浮片 体外累积释放率 |
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| Preparation of paeoniflorin gastric floating tablets |
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| Abstract:Objective To prepare paeoniflorin gastric floating tablets and to optimize the formulation. Methods Gastric floating tablets were prepared by wet granulation, with floating performance and in vitro cumulative release rate as evaluat indicators, single factor tests and orthogonal design test were adopted for the optimal formulation. Results With HPMC K4M 20% as reinforcing materials, NaHCO3 15% as gas agent, PVPP 7% as the release of accelerator, lactose as a filler, the obtained gastric floating tablet can immediately play bleaching, continued to float more than 12 hours, and the cumulative release rate was more than 90%. Conclusion The optimal formulation of paeconiflorin floating tablet has achieved a sustained and slow release request floating, the operability is good. |
| keywords:paeoniflorin gastric floating tablet cumulative release rate in vitro |
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