| 蓝萼甲素的药理活性及其机制和毒理作用的研究进展 |
| 投稿时间：2015-10-28 修订日期：2016-01-25 点此下载全文 |
| 引用本文：迟晴晴,王强,钟延强.蓝萼甲素的药理活性及其机制和毒理作用的研究进展[J].药学实践杂志,2016,34(2):124~128 |
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| 中文摘要:蓝萼甲素(glaucocalyxin A,GLA)是一种具有对映15-氧-16贝壳杉烯(ent-15-oxo-16-kaurene)骨架结构的二萜类化合物。其具有心血管保护、内皮保护、抗凝血、抗乙肝病毒、抗肿瘤、抑菌、抗炎、耐缺氧、免疫抑制及调节钙离子浓度等多种药理作用,并且有很高的体内安全性。民间常用蓝萼香茶菜治疗肝炎、胃炎、乳腺炎、腹痛、关节痛等疾病,临床上蓝萼香茶菜主要用于治疗冠心病、心绞痛、脑供血不足等缺血、缺氧性心脑血管疾病。本研究将对蓝萼甲素的药理作用及其机制和毒理学作用做一总结。 |
| 中文关键词:蓝萼甲素 香茶菜 药理作用 毒理作用 |
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| Advances on the research of the pharmacological activity mechanism and toxicology of Glaucocalyxin A |
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| Abstract:Glaucocalyxin A(GLA) is a kind of diterpenoid enantiomers with organic chemical structure of en-15-oxo-16-kaurene. It has various pharmacological activities, such as cardiovascular and endothelium cellular protection, anti-blood coagulation, anti-Hepatitis B Virus(HBV), anti-tumor, anti-bacteria, anti-inflammation, hypoxic tolerance, immunomodulation and Ca2+ concentration regulation effect, where as its in vivo safety is quite good. As a folk medicine, it is conventionally used to treat hepatitis, gastritis, mastitis, stomachache and arthralgia. It is also used for ischemic and/or hypoxic cardio-cerebrovascular diseases such as coronary heart diseases, stenocardia and chronic cerebral circulation insufficiency in clinic. This review gives a summary of the pharmacological effects, biological mechanism, and toxicity of Glaucocalyxin A. |
| keywords:Glaucocalyxin A Rabdosia(BI.) Hassk pharmacological activity toxicology |
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