| 氨曲南与头孢他啶治疗下呼吸道感染的荟萃分析 |
| 投稿时间：2014-10-21 修订日期：2015-03-18 点此下载全文 |
| 引用本文：鲍思蔚,张誉艺,胡燕鸣,翟晓波,何志高.氨曲南与头孢他啶治疗下呼吸道感染的荟萃分析[J].药学实践杂志,2016,34(1):83~85,89 |
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| 基金项目:"十二五"国家科技支撑计划课题"安全合理用药评价和干预技术研究与应用"(2013BAI06B04) |
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| 中文摘要:目的 评价氨曲南与头孢他啶治疗下呼吸道感染的临床疗效与安全性差异。 方法 通过检索MEDLINE、EMBASE、Pubmed、Cochrane library、CNKI、维普、万方等数据库获得相关检索文献,采用Review Manager 5.2进行系统评价。 结果 荟萃分析(Meta)结果显示,氨曲南治疗下呼吸道感染的总有效率显著高于头孢他啶组(RR=1.15,95%CI为1.09~1.21);细菌清除率、不良反应发生率两组无显著性差异(RR=1.03,95%CI为0.98~1.09;RR=0.66,95%CI为0.39~1.12)。 结论 氨曲南治疗下呼吸道感染的临床疗效优于头孢他啶。 |
| 中文关键词:下呼吸道感染 氨曲南 头孢他啶 荟萃分析 |
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| Meta-analysis on treatment of lower respiratory tract infection of azatreonam or ceftazidime |
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| Abstract:Objective The aim of the study is to evaluate clinical efficacy and safety of azatreonam or ceftazidime on treatment of lower respiratory tract infection. Methods Four English databases (MEDLINE、EMBASE、Pubmed、Cochrane library) and three Chinese databases (CNKI、VIP、WANFANG) were searched. Meta-analysis was performed using Review Manager 5.2. Results The Meta-analysis revealed azatreonam was superior to ceftazidime in total efficiency (RR=1.15,95% CI is 1.09-1.21). No significant differences are seen between azatreonam and ceftazidime (RR=1.03,95% CI is 0.98-1.09) on the bacterial eradication rates or the incidence of adverse reactions (RR=0.66,95% CI is 0.39-1.12). Conclusion Azatreonam is more effective than ceftazidime on the treatment of lower respiratory tract infection in the clinical practice. |
| keywords:lower respiratory tract infection azatreonam ceftazidime Mata-analysis |
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