| 芦丁片剂药学综合性实验的流程及方法研究 |
| 投稿时间：2014-06-25 修订日期：2015-01-12 点此下载全文 |
| 引用本文：陈莉,杜红丽,曾仁韬,张叶叶,鲁莹,蔡国君.芦丁片剂药学综合性实验的流程及方法研究[J].药学实践杂志,2015,33(4):359~362 |
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| 中文摘要:目的 以芦丁为模型药物,探讨新药片剂制备及药效学评价的多学科综合性实验流程和方法。 方法 采用薄层色谱定性鉴别槐米中的芦丁成分;采用高效液相色谱法测定槐米中芦丁含量及芦丁精制品的含量;采用紫外分光光度法测定芦丁片含量;采用离体大鼠胸主动脉环舒张实验考察芦丁的药效;利用粉末直接压片法制备芦丁片剂。 结果与结论 本实验完成了槐米的质量评价,槐米中芦丁的提取纯化、含量测定,芦丁药效学考察及芦丁片处方工艺研究等内容,提高了实验操作技能,实践了芦丁临床前研究的部分内容。 |
| 中文关键词:多学科综合性实验 芦丁 药效学 片剂 |
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| Research on the technological process and methods of the comprehensive pharmaceutical experiment of rutin tablets |
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| Abstract:Objective To imitate the development process of new drugs with rutin as the model and to do multidisciplinary experiments of preparation and pharmacodynamics of rutin tablets. Methods Thin-layer chromatography was used to identify rutin in Pagodatree flower bud. High-performance liquid chromatography was used for quantitative determination of rutin in Pagodatree flower bud and rutin products. The vasodilatation effect of rutin was investigated. The preparation of rutin tablets was completed. Results and Conclusion We completed the identification of Pagodatree flower bud, extraction and purification of rutin from Pagodatree flower bud, the assay of rutin, the pharmaco-dynamics study and the formulation of rutin tablets. The experiments helped the postgraduates to be familiar with the research process of new drugs and to improve their experimental operation skills. |
| keywords:multidisciplinary experiments rutin pharmacodynamics tablets |
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