| 不同制法纳米银的抗真菌活性研究 |
| 投稿时间：2014-03-11 修订日期：2015-01-14 点此下载全文 |
| 引用本文：张璐璐,苗琦,叶招浇,李洪娇,姜远英,曹永兵.不同制法纳米银的抗真菌活性研究[J].药学实践杂志,2015,33(4):328~330,358 |
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| 中文摘要:目的 探讨不同制备方法得到的纳米银的体外抗真菌活性。 方法 采用微量液基稀释法测定纳米银对氟康唑不同敏感型白色念珠菌的最低抑菌浓度;棋盘实验测定纳米银与氟康唑的协同抗真菌作用。 结果 不同制备方法得到的纳米银对白色念珠菌的抑制作用不同,对敏感菌与耐药菌的抑制作用无显著差异,与氟康唑合用对白色念珠菌能产生协同作用。 结论 不同制备方法得到的纳米银在体外的抗真菌作用有差异,但与氟康唑合用可产生协同作用。 |
| 中文关键词:纳米银 白色念珠菌 抑菌作用 |
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| Fungistasis of nanometer silvers synthesized by different methods on Candida albicans |
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| Abstract:Objective To explore the in vitro fungistasis of nanometer silvers made by different methods on Candida albicans. Methods The minimal inhibitory concentrations (MICs) of Candida albicans strains stimulated to silver nanoparticles were determined by microdilution method.The combination effects of silver nanoparticles with fluconazole were determined by chess board check assay. Results The inhabitation effect of two kinds of silver nanoparticles were different on the growth of Candida albicans.Silver nanoparticles had a synergistic effect with fluconazole on Candida albicans. Conclusion The two kinds of silver nanoparticles had various antifungal activities in vitro and had a synergistic effect with fluconazole on Candida albicans. |
| keywords:silver nanoparticles Candida albicans fungistasis |
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