| 二氢黄酮类化合物的合成研究进展 |
| 投稿时间：2013-11-28 修订日期：2014-04-21 点此下载全文 |
| 引用本文：梁海,向卓,张学辉,吴久鸿.二氢黄酮类化合物的合成研究进展[J].药学实践杂志,2015,33(2):97~101,130 |
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| 基金项目:国家自然科学基金项目(No.81072546) |
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| 中文摘要:综述二氢黄酮类化合物的合成研究进展, 总结已报道的各种类型的二氢黄酮合成方法, 为二氢黄酮类新药研发提供方法学支持。合成方法包括:查尔酮环合、Friedel-Crafts反应、Knoevenagel缩合和Hoesch单酰基化反应, 以及二氢黄酮的不对称合成, 并简要介绍无溶剂合成二氢黄酮等"绿色"化学方法。 |
| 中文关键词:二氢黄酮类化合物 查尔酮 环合 合成 |
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| Reviews on flavanone compounds synthesis research |
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| Abstract:Research progress of flavanone compounds synthesis was reviewed, various types of synthesis methods of flavanone compounds were summarized, and methodological support for flavanone compounds in new drug research and development was provided. Research progress in synthesis of flavanone compounds includes chalcone cyclization, Friedel-Crafts reaction, Knoevenagel condensation, Hoesch single acetoxylation, and asymmetric synthesis of flavanone compounds. Solvent-free synthesis of flavanone compounds and other green chemistry methods were also introduced. |
| keywords:flavanone compounds chalcone cyclization synthesis |
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