| 西药常规治疗联用通心络胶囊治疗冠心病心绞痛疗效的荟萃分析 |
| 投稿时间：2013-02-06 修订日期：2013-11-07 点此下载全文 |
| 引用本文：樊蓉,任天舒,赵庆春,史国兵.西药常规治疗联用通心络胶囊治疗冠心病心绞痛疗效的荟萃分析[J].药学实践杂志,2015,33(1):83~87 |
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| 中文摘要:目的 系统评价西药常规合用通心络胶囊治疗冠心病心绞痛的疗效。方法 运用计算机检索2000年至2011年中国期刊网全文数据库(CNKI)、万方数据库、维普数据库和PubMed,并结合手工文献检索相关杂志、会议论文和学位论文,收集国内外公开发表的西药常规治疗+通心络胶囊治疗冠心病心绞痛的随机对照试验(RCT)。由2名研究者独立选择试验、评价质量、提取数据,并交叉核对。使用RevMan 4.2.2软件进行分析。结果 纳入西药常规+通心络胶囊(治疗组)与西药常规(对照组)对照评价治疗冠心病心绞痛有效率的RCT 11项,其中9项评价了心电图异常的改善率,11项评价了心绞痛症状的改善率。心电图疗效评价,治疗组相对于对照组相对危险度(RR)值为1.40(95% CI:1.28~1.54),P<0.01;心绞痛症状疗效评价,治疗组相对于对照组RR值为1.25(95% CI:1.18~1.32),P<0.01。治疗组仅个别病例有轻微胃肠不适。结论 在西医常规治疗的基础上合用通心络胶囊,能有效提高临床疗效,用药安全。 |
| 中文关键词:中西药联用 冠心病心绞痛 疗效 荟萃分析 |
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| Meta-analysis on clinical study of western routine treatments combined with Tongxinluo capsule in treatment of angina pectoris |
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| Abstract:Objective To assess the effectiveness of western routine treatments combined with Tongxinluo capsule for angina pectoris. Methods The randomized controlled trials(RCTs) of western routine treatments combined with tongxinluo capsule for angina pectoris were collected through searching on computer from the following databases,CNKI(2000-2011),WanFang Data(2000-2011),WeiPu Data(2000-2011),PubMed(2000-2011) and manual search relevant journals,conference papers. Results A total of 11 studies were included and improvement rate of abnormal ECG were estimated in 9 studies and improvement rate of symptoms of angina were estimated in 11 studies.ECG clinical evaluation of the treatment group relative to the control group,relative risk (RR) value was 1.40 (95% CI:1.28-1.54),P<0.01,symptoms of angina clinical evaluation,treatment group relative to the control group RR value of 1.25 (95% CI:1.18-1.32),P<0.01.Only slight gastrointestinal discomfort were found in treatment group. Conclusion Tongxinluo capsule in combination on the basis of conventional western treatment could effectively improve the clinical efficacy and drug safety. |
| keywords:combination of Chinese and western medicine angina pectoris efficacy Meta-analysis |
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