| 复方川芎滴丸制备工艺再探讨 |
| 投稿时间：2013-09-12 修订日期：2014-02-25 点此下载全文 |
| 引用本文：张炜,魏燕,马守江.复方川芎滴丸制备工艺再探讨[J].药学实践杂志,2015,33(1):60~62 |
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| 中文摘要:目的 优选复方川芎滴丸的最佳制备工艺。方法 以药物与基质的配比、滴制温度、冷却液的温度为考察因素,采用正交试验设计,以滴丸的圆整度、丸重差异、溶散时限、外观质量的综合评分为评价指标,优选滴丸的成型工艺;以滴距、滴速为考察因素,优选最佳滴制工艺。结果 滴丸制备的最佳条件为药物中间体与基质配比1:2,滴制温度80℃,冷却剂温度15~20℃,滴距5 cm,滴速40 gtt/min。结论 该制备工艺合理,简便,易于控制,适用于本制剂的制备。 |
| 中文关键词:复方川芎滴丸 制剂工艺 正交试验 |
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| Re-evaluation on preparation technology of compound Chuanxiong dropping pills |
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| Abstract:Objective To optimize the preparation technology of compound Chuanxiong dropping pills. Methods Ratio of intermediate material to matrix,dripping temperature and condensate temperature were used as factors,with spherical degree,pill weight variatcon,dissolve time limit coefficient and appearance quality as indexes,the forming technology of compound Chuanxiong dropping pill was optimized by orthogonal test.The dropping preparation technology was optimized using dropping distance,dropping speed as factors. Results The optimal preparation conditions were as follows:ratio of intermediate material to matrix was 1:2,dropping temperature was 80℃,temperature of condensate was 15-20℃,dropping distance was 5 cm,dropping speed was 40 drops/min. Conclusion The preparation technology was reasonable,simple and easy to control for the preparation of compound Chuanxiong dropping pills. |
| keywords:compound Chuanxiong dropping pill preparation technology orthogonal test |
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