| 甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展 |
| 投稿时间：2013-06-13 修订日期：2013-12-02 点此下载全文 |
| 引用本文：卜晓琳,毕新岭,徐晓光,高志祥,李慧,顾军.甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展[J].药学实践杂志,2014,32(6):405~408 |
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| 基金项目:浦东新区卫生系统优秀青年医学人才培养计划(PWRq2013-02). |
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| 中文摘要:甲状旁腺素(PTH)和甲状旁腺素相关肽(PTHrP)是一类多肽类激素,它们具有相似的基因结构、相同的膜受体,在人体钙、磷代谢过程中起着重要的调节作用。PTH和PTHrP及其受体除表达于肿瘤组织外,在皮肤、毛囊等正常组织也有表达。它们对表皮增殖分化、毛发生长的生理作用等方面,有望成为银屑病等常见皮肤病的治疗新靶点。 |
| 中文关键词:甲状旁腺素 甲状旁腺素相关肽 皮肤病 |
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| The research progress of parathyroid hormone and parathyroid hormone-related peptide in skin disease |
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| Abstract:Parathyroid hormone/parathyroid hormone-related peptides are polypeptide hormones. They have similar gene structure and same membrane receptor. They play great roles in regulating the calcium and phosphorus metabolism in vivo. PTH/PTHrP and their receptors are expressed in tissues of tumor,skin, hair follicle and other normal tissues. Because of their physiological action on the proliferation and differentiation of epidermis and hair growth,they may be a potential therapeutic target for some skin diseases including psoriasis. |
| keywords:parathyroid hormone parathyroid hormone-related peptide skin disease |
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