| 清蛋白作为药物载体的PEG化修饰研究进展 |
| 投稿时间：2013-08-11 修订日期：2013-12-25 点此下载全文 |
| 引用本文：周琴琴,陈建明.清蛋白作为药物载体的PEG化修饰研究进展[J].药学实践杂志,2014,32(4):241~245,265 |
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| 中文摘要:清蛋白(白蛋白)是一种理想的药物载体,但由于其在体内半衰期短以及易被酶降解等缺点限制了其应用,然而根据其具有多个修饰位点的结构特点,可通过PEG修饰延长循环时间,阻碍酶的作用等。目前,PEG修饰清蛋白仍处于研究阶段,已有较多关于PEG修饰清蛋白的研究,例如PEG修饰所起的作用、对清蛋白及其制剂的影响,以及修饰位点的选择等。本文对清蛋白的PEG化修饰的相关研究进行综述。 |
| 中文关键词:清蛋白 PEG化 半衰期 药剂学性质 修饰位点 |
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| Research advances of PEGylation modification of albumin as drug carrier |
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| Abstract:Albumin is an ideal drug carrier, but its application was limited because of the shortcomings of short half-life and susceptible to enzymatic degradation in vivo.However, according to its structural features, albumin has a plurality of modification sites, which can be modified by PEG modifier to extend the cycle time and obstruct the action of the enzyme.Currently, the PEG-modified albumin is still in the research stage, and there have been many studies about PEG-modified albumin, such as the role of PEG modification, the effects on albumin and its preparations and the modification sites selection.The article reviewed the related studies about the PEGylation of albumin. |
| keywords:albumin PEGylation half-life pharmaceutical characterization modification sites |
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