| 葡萄籽原花青素B2磷脂复合物的制备研究 |
| 投稿时间：2013-08-08 修订日期：2013-09-29 点此下载全文 |
| 引用本文：苗智如,徐超斗,陆帅,蒋国军.葡萄籽原花青素B2磷脂复合物的制备研究[J].药学实践杂志,2014,32(1):31~34 |
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| 基金项目:杭州市科学技术局医疗卫生科研项目(20100633B26);杭州市萧山区科学技术局重点科研项目(2010225). |
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| 中文摘要:目的 制备葡萄籽原花青素磷脂复合物,考察其理化性质,研究磷脂复合物制剂成型工艺。方法 以葡萄籽原花青素与磷脂的复合率为评价标准,再以复合率为指标确定复合物制备工艺;研究原花青素B2磷脂复合物的理化性质包括脂水分配系数及溶解性能等;探讨葡萄籽原花青素磷脂复合物的制剂成型工艺。结果 优化工艺的复合率可达97%。原花青素B2磷脂复合物的油水分配系数与原花青素B2相比明显增大,预示其体内吸收有可能提高。原花青素磷脂复合物流动性尚可,但黏性强,相对临界湿度小,引湿性较强。结论 确定了制备葡萄籽原花青素磷脂复合物的最佳工艺,该复合物明显改善了原药的理化性质。 |
| 中文关键词:葡萄籽 原花青素 磷脂复合物 |
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| Preparation of proanthocyanidins phospholipids complex |
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| Abstract:Objective To prepare proanthocyanidins phospholipids complex, investigate the physicochemical properties and study the formulation. Methods Proanthocyanidins phospholipids complex was prepared and optimized by solvent evaporation method and physicochemical characteristics of the complex were investigated by means of apparent solubility studies.Results The average entrapment efficiencies of phospholipid complex for proanthocyanidins of grasp seed was 97%. Moreover, there was a great improvement of the solubility of proanthocyanidins phospholipid complex both in water and n-octanol. Conclusion The best method to proanthocyanidins phospholipid complex was achieved, and the physicochemical properties were significantly better from those of proanthocyanidins. |
| keywords:grape seed proanthocyanidins phospholipid complex |
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