| 硬脂酸镁在直接压片工艺中产生的软化效应 |
| 投稿时间：2013-06-28 修订日期：2013-11-06 点此下载全文 |
| 引用本文：王涛.硬脂酸镁在直接压片工艺中产生的软化效应[J].药学实践杂志,2014,32(1):19~22 |
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| 中文摘要:脂酸镁又名十八酸镁,在粉末直接压片工艺中具有重要作用,但是硬脂酸镁的使用,往往会对片剂产生一定的软化效应。从直压辅料的分类、物料粒径大小、辅料与硬脂酸镁的混合时间以及硬脂酸镁使用浓度等方面,简要分析产生此种软化效应的原因以及影响其大小的因素,以期为实际生产中提高粉末直接压片工艺有所借鉴和帮助。 |
| 中文关键词:硬脂酸镁 润滑剂 直压辅料 黏冲现象 |
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| Decreasing tablet strength of magnesium stearate in direct compression technology |
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| Abstract:Magnesium stearate as a lubricant plays an important role in the direct compression of tablet technology, but the use of magnesium stearate often causes negative effect on tablet strength. The reasons of decreasing tablet strength from the aspects of excipients classification, particle size, blending time and lubricant concentration were briefly analyzed, which was helpful for the promotion and improvement of the tablet manufacturing level. |
| keywords:magnesium stearate lubricant directly compressible excipients sticking |
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