| 2-(取代苯氧基)-5-羟基嘧啶类化合物的制备方法研究 |
| 投稿时间：2012-10-24 修订日期：2013-04-25 点此下载全文 |
| 引用本文：魏海洋,刘娜,周有骏,吕加国,朱驹.2-(取代苯氧基)-5-羟基嘧啶类化合物的制备方法研究[J].药学实践杂志,2013,31(6):446~447,469 |
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| 基金项目:国家自然科学基金(20972187). |
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| 中文摘要:目的 探索2-取代苯氧基-5-苯甲氧基嘧啶、2-取代苯氧基-5-羟基嘧啶类化合物的制备方法。方法 以2-氯-5-羟基嘧啶为起始原料,经溴苄羟基保护、威廉森醚合成法、脱苄基保护等多步反应制得目标化合物。结果 采用该合成路线制得13个未见文献报道的取代苯氧基嘧啶类化合物。结论 本研究提出了一条操作简便、条件温和的全新苯氧基嘧啶类化合物合成方法。 |
| 中文关键词:2-取代苯氧基-5-苯甲氧基嘧啶 2-取代苯氧基-5-羟基嘧啶 合成 |
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| Synthesis of 2-substitudephenoxy-5-benzyloxypyrimidines compounds |
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| Abstract:Objective To prepare 2-substitudephenoxy-5-benzyloxypyrimidines and 2-substitudephenoxy-5-hydroxypyrimidines which had not been reported. Methods The target compounds were prepared from 2-chlorine-5-hydroxypyrimidine through hydroxy protection, Williamsom reaction and reduction of benzyl group. Results The synthetic process provided a simple, easy diposal procedure and high overall yield. Fourteen new phenoxy pyrimidines compounds were prepared. Conclusions It was a new synthetic method which was easy to operate with moderate reaction conditions. |
| keywords:2-substitudephenoxy-5-benzyloxypyrimidines 2-substitudephenoxy-5-hydroxypyrimidines synthesis |
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