| 结合微管蛋白位点的小分子血管阻断剂的研究进展 |
| 投稿时间：2012-10-07 修订日期：2013-04-01 点此下载全文 |
| 引用本文：李唯,周峰,郑灿辉,周有骏.结合微管蛋白位点的小分子血管阻断剂的研究进展[J].药学实践杂志,2013,31(6):401~404,423 |
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| 基金项目:国家自然科学基金(21172260);上海市基础研究重点课题(09JC1417500). |
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| 中文摘要:血管阻断剂(vascular disrupting agents,VDAs)是能选择性损伤肿瘤相关血管的一类抗肿瘤药物。这类药物通过选择性地破坏肿瘤相关血管,阻断肿瘤组织的氧气和营养物质供应,造成继发的肿瘤细胞死亡,从而达到靶向治疗肿瘤的目的。目前已有10多个作用于微管蛋白的血管阻断剂进入临床研究,显示出良好的开发应用前景。本文对目前进入临床研究的VDAs进行综述。 |
| 中文关键词:微管蛋白 血管阻断剂 抗肿瘤 研究进展 |
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| Progress on microtubulin-site vascular disruption agents |
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| Abstract:Vascular disrupting agents (VDAs) are a novel class of the antitumor agents that selectively damage the established tumor vessel. This kind of agents can selectively damage the tumor vascular, which apply adequate oxygen and nutrient for tumor growth and metabolism, and result in the tumor cell necrosis. In recent years, a number of VDAs that interact with microtubule had been involved in clinical trials, and showed good prospects for development and application, which were summarized in this paper. |
| keywords:microtubulin vascular disrupting agents (VDAs) anticancer |
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