| 比浊法测定多西环素效价含量 |
| 投稿时间：2012-09-11 修订日期：2013-02-21 点此下载全文 |
| 引用本文：应茵,楼娉婷.比浊法测定多西环素效价含量[J].药学实践杂志,2013,31(5):368~370 |
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| 中文摘要:目的 本文建立了比浊法测定多西环素效价的方法,为比浊法的进一步应用提供了依据。方法 以金黄色葡萄球菌为试验菌,采用比浊法测定多西环素的含量,并对微生物比浊法、管碟法测定多西环素制剂的结果进行比较。结果 多西环素的线性范围为1.0~3.3 u/ml( r=0.997 9),片剂平均回收率为99.84%,方法重复性良好(RSD为0.42%)。同时,多西环素制剂的比浊法和管碟法测定结果无显著性差异,可信限率均小于5%。结论 比浊法具有简便、精确、快捷的特点,可以应用于该产品的质量控制。 |
| 中文关键词:多西环素 效价含量 比浊法 |
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| Determination the microbiological assay of doxycycline by turbidimetric method |
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| Abstract:Objective To establish a method for determining the microbial assays of doxycycline by turbidimetric method in order to provide a basis for further development.Methods Staphylococcus aureus was chosen as the test organism that the microbiological assay of doxycycline was determined by turbidimetric method while a comparision of turbidimetric method and cyclinder-plate was carried out.Results The linearity range of doxycycline was 1.0~3.3 u/ml( r=0.997 9).The average recoveries of doxycycline was 99.84%.The method had a good reproducible( RSD:0.42%).The microbiological assay of doxycycline pharmaceutical preparations were united which determined by turbidimetric method and cylinder-plate method. The confidence rates were also less than 5%.Conclusion The results indicated that the turbidimetric method could be used as quality control because of its convenience,accuracy and quickness. |
| keywords:doxycycline microbiological assay turbidimetric method |
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