| 盐酸尼卡地平缓释微丸的制备 |
| 投稿时间：2012-09-04 修订日期：2013-04-08 点此下载全文 |
| 引用本文：原丽慧,卞俊.盐酸尼卡地平缓释微丸的制备[J].药学实践杂志,2013,31(4):258~261 |
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| 中文摘要:目的 制备盐酸尼卡地平缓释微丸,并考察其体外释药的影响因素。方法 采用底喷式流化床包衣法,以空白丸芯为基础制备速释微丸,乙基纤维素水分散体为包衣材料制备盐酸尼卡地平缓释微丸,考察其包衣处方及工艺的影响因素。结果 所得缓释微丸在2、6、12 h的累积释药百分率分别为24%、69%、87%,体外释放曲线符合一级方程。结论 制备的微丸缓释效果理想,且制备工艺简单,操作方便。 |
| 中文关键词:盐酸尼卡地平 乙基纤维素水分散体 缓释微丸 流化床 |
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| Preparation of nicardipine hydrochloride sustained-release pellets |
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| Abstract:Objective To prepare nicardipine hydrochloride sustained-release pellets and investigate the influencing factors of the drug release in vitro. Methods The rapid-release pellets were prepared by fluidized bed coating method based on blank pill core and then nicardipine hydrochloride sustained-release pellets were prepared with surelease. The factors to influence the drug release behaviors and their properties were evaluated. Results The release percentage of the sustained-release pellets could be controlled by 24%, 69%, 87% at 2 h, 6 h, 12 h respectively, the drug release mechanism in vitro followed first-order equations.Conclusion The pellets showed an obviously sustained-release effect.The preparation process was simple and convenient. |
| keywords:nicardipine hydrochloride surelease sustained-release pellets fluidized bed |
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