| 3种药物治疗骨质疏松症的成本-效果分析 |
| 投稿时间：2012-05-03 修订日期：2012-10-29 点此下载全文 |
| 引用本文：李毓芹.3种药物治疗骨质疏松症的成本-效果分析[J].药学实践杂志,2013,31(2):143~144,150 |
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| 中文摘要:目的 探讨3种药物治疗骨质疏松症的经济效果。方法 将135例患者随机分成3组,A组给予阿仑膦酸钠维D3片70 mg/2 800 IU,每周1次,晨起1片;B组给予鲑鱼降钙素鼻喷剂,每日1次,每次100 IU;C组给予唑来膦酸注射液4 mg,每年1次,3组疗程均为1年,3组患者均同时补充钙剂,进行疗效观察,并采用成本-效果分析法进行经济学分析。结果 在骨疼痛症状改善方面,A组:66.67%、B组:55.56%、C组:80.00%,C组疗效高于A组、B组,3组疗效有统计学意义(P<0.05);经济学方面,A组、B组、C组的成本效果比分别是59.52、43.61、46.70,B组优于A组、C组,但B组疗效最低。结论 C组为优选方案。 |
| 中文关键词:阿仑膦酸钠维D3片 鲑鱼降钙素鼻喷剂 唑来膦酸注射液 骨质疏松症 药物经济学 |
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| Cost-effectiveness analysis of three kinds of drugs for osteoporosis |
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| Abstract:Objective To investigate economic effects of three kinds of drugs in treatment of osteoporosis.Methods 135 cases were divided into three groups, A group with alendronate sodium and vitamin D3 tablets 70 mg/2 800 IU, once a week, early morning,B group with salmon calcitonin nasal spray, once a day every time 100 IU, C group with zoledronicacid injection 4 mg, once a year. All groups were treated for one year, three groups of patients were added calcium at the same time. Efficacy was observed. Cost-effectiveness analysis was used. Results In the improvement of bone pain, A group was 66.67%, B group was 55.56%, C group was 80%. C group was higher than those in group A, group B, group efficacy was statistically significant in three groups(P<0.05); The effectiveness ratio of A group, B group, C group was 59.52,43.61,46.70 respectively. B group was superior to A group and C group in the terms of economic, but group B had the lowest efficacy in all groups. Conclusion C group was the optimal solution for osteoporosis. |
| keywords:alendronate sodium and vitamin D3 tablets salmon calcitonin nasal spray zoledronicacid injection osteoporosis pharmaco-economics |
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