| 驻极体及联用氮酮对环孢菌素A的体外透皮促渗作用 |
| 投稿时间：2012-04-24 修订日期：2012-09-10 点此下载全文 |
| 引用本文：刘鸿越,江键,马琳,梁媛媛,董法杰,崔黎丽.驻极体及联用氮酮对环孢菌素A的体外透皮促渗作用[J].药学实践杂志,2012,30(6):440~442,466 |
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| 基金项目:国家自然科学基金资助(50977089);上海市自然科学基金资助(10ZR1437600). |
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| 中文摘要:目的 研究驻极体及联用氮酮对环孢菌素A的体外透皮促渗作用。方法 采用常温电晕充电的-500V,-1 000 V、-2 000 V聚丙烯为驻极体,1%、3%、5%的氮酮为化学促渗剂,利用透皮实验仪和HPLC,研究驻极体、氮酮以及驻极体联用氮酮对环孢菌素A溶液的透皮促渗作用。结果 不同表面电压的驻极体以及不同浓度的氮酮均能提高环孢菌素A的累积渗透量;-1 000 V驻极体与1%氮酮联用,环孢菌素A的累积渗透量较1%氮酮单独使用略有提高。结论 负极性驻极体、氮酮对环孢菌素A均有促渗作用,负极性驻极体与氮酮联用对环孢菌素A没有明显联合促渗作用。 |
| 中文关键词:驻极体 环孢菌素A 氮酮 透皮吸收 透皮促进作用 |
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| Penetration enhancement of electret and united Azone on cyclosporin A transdermal delivery in vitro |
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| Abstract:Objective To study the penetration enhancement of electret and united Azone on cyclosporin A transdermalde livery in vitro. Methods Using corona charged -500 V, -1 000 V and -2 000 V polypropylene (PP) as electrets, 1%, 3% and 5% Azone as chemical enhancers, the transdermal behaviours of the cyclosporine A in solution were evaluated by modified Franze diffusion cell method. The concentration of cyclosporine A was measured by HPLC. Results All the electrets and chemical enhancers used in this study enhanced the cumulative penetration amount of the drug. The combination of -1 000 V and 1% Azone showed a slight increase in cumulative penetration amount of the drug compared with that of the 1% Azone used alone. Conclusion Both the negative electret and Azone could enhance the transdermal delivery of cyclosporin A individually. But negative electret and Azone had no synergistic enhancing effect on cyclosporin A transdermal delivery. |
| keywords:electret cyclosprin A azone transdermal delivery transdermal enhancement |
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