| 5-羟基-4'-硝基-7-取代苄氧基-异黄酮的合成及抗肿瘤活性 |
| 投稿时间：2012-04-22 修订日期：2012-07-23 点此下载全文 |
| 引用本文：王晓华,王巍,刘超美.5-羟基-4'-硝基-7-取代苄氧基-异黄酮的合成及抗肿瘤活性[J].药学实践杂志,2012,30(6):427~429 |
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| 中文摘要:目的 设计合成7-取代苄氧基-5-羟基-4'-硝基金雀异黄素衍生物,并进行体外抗肿瘤活性测试。方法 以氯苄为起始原料,经取代、硝化、Friedel-Crafts反应、环合和苄基化得到目标化合物。结果 合成了2类重要中间体:4' -硝基脱氧安息香和4'-硝基金雀异黄素和7个目标化合物,并经元素分析和1H NMR确证其结构。结论 7位羟基引入苄基不能提高该类化合物的抗肿瘤活性。 |
| 中文关键词:异黄酮 金雀异黄素 化学合成 抗肿瘤活性 |
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| Synthesis and antitumor activities of 5-hydroxy-4'-nitro-7-substituted benzyloxy-isoflavone |
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| Abstract:Objective To design and synthesize genistein's derivatives:5-hydroxy-4'-nitro-7 -substituted benzyloxo-isoflavones and evaluate the antitumor effects in vitro. Methods Benzyl chloride was used as the starting reagent, to obtain title compounds by multi-step reaction:substitution, nitration, Friedel-Crafts reaction, cyclation reaction and benzylation. Results Two important intermediates:4'-nitrodeoxybenzoin and 4'-nitrogenistein and seven title compounds were synthesized, which had been identified by elemental analysis and 1H NMR.Conclusion Introduction of simple substituted benzyl group to 7-posion hydroxy could not enhance the antitumor effects of this type of compounds. |
| keywords:isoflavone genistein chemical synthesis antitumor activity |
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