| 蛋白质结晶的新进展与药物设计 |
| 投稿时间：2010-07-22 修订日期：2011-07-11 点此下载全文 |
| 引用本文：陈维敬,仲维清.蛋白质结晶的新进展与药物设计[J].药学实践杂志,2012,30(2):81~85,136 |
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| 基金项目:国家自然科学基金资助项目(20371050). |
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| 中文摘要:蛋白质是生命的基础,其功能与它的三维结构密切相关,关于蛋白质的结构信息,对科学家根据结构同源性确定药物靶标以及发现新的药物靶标等方面均有至关重要的作用。因此,蛋白质晶体的获得及其与药物设计的关系日益受到重视,已成为生命科学中的一个重要领域,本文主要综述了蛋白质结晶技术的最新研究进展以及在药物设计中的应用。 |
| 中文关键词:蛋白质 晶体 靶点 药物设计 |
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| New progress of protein crystallization and drug design |
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| Abstract:Protein was the foundation of all life, and its function was closely related to its three-dimensional structure. The structure information of proteins was crucial for the determination of drug targets and helped scientists to discover new drug targets according to the structure homology between the protein targets and drugs. Therefore, the availability of protein crystal, which was the basis for its structure information and the drug design, had become an important field in life science. The latest research progresses of protein crystallization technology and its application in the drug design were summarized in this review. |
| keywords:protein crystallization target drug design |
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