| 盐酸苯达莫司汀合成工艺的改进 |
| 投稿时间：2011-01-05 修订日期：2011-05-09 点此下载全文 |
| 引用本文：蔡瞻,姜志辉,赵明珠,张大志,臧成旭,黄景华.盐酸苯达莫司汀合成工艺的改进[J].药学实践杂志,2011,29(6):453~454 |
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| 中文摘要:目的 改进盐酸苯达莫司汀的合成工艺,以提高产品纯度。 方法 以[1-甲基-2-(4'-丁酸乙酯基)-5-硝基]-1H-苯并咪唑为起始原料,经氢化还原、取代、水解和成盐等反应制得盐酸苯达莫司汀。 结果 优化后的制备工艺成本低,操作简便,可获得高纯度的盐酸苯达莫司汀。 结论 新工艺产率达到62%,适合工业生产。 |
| 中文关键词:盐酸苯达莫司汀 抗肿瘤 合成 |
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| Optimization of synthetic process of bendamustin |
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| Abstract:Objective To optimize the synthetic process of bendamustin for high purity. Methods Bendamustin was prepared from 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester by reduction,substitution,hydrolization and salification,successively. Results A good process for preparation of bendamustin was successfully achieved with low cost, easy operation and high purity. Conclusion The overall yield of the new process was 62%, which was more suitable for industrial production. |
| keywords:bendamustin antitumor synthesis |
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