| 乙醇-水溶剂体系结晶阿奇霉素的晶体差异分析 |
| 投稿时间：2011-03-01 修订日期：2011-05-24 点此下载全文 |
| 引用本文：蒋德华,林锦明,陈建明,王小燕,李渊源,周长江.乙醇-水溶剂体系结晶阿奇霉素的晶体差异分析[J].药学实践杂志,2011,29(5):356~357,365 |
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| 基金项目:第二军医大学创新能力培养计划:反溶剂重结晶法研究固体药物多晶型(MS2010042). |
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| 中文摘要:目的 探索不同条件下乙醇-水溶剂体系产生的阿奇霉素晶体差异。 方法 以乙醇-水为溶剂体系,采用不同的结晶条件制备阿奇霉素晶体,运用差热分析(TDA)和X-ray衍射法(XRD)对阿奇霉素晶体进行初步研究,并用核磁共振(C-NMR)对阿奇霉素样品进行了确证。 结果 得到了4种具有不同DTA和XRD特征的晶型阿奇霉素样品。 结论 获得了阿奇霉素多晶型相关的热力学数据、XRD特征、不同晶型的结晶条件(温度、压强、析晶方式等),为晶体结晶方法的研究开阔了思路。 |
| 中文关键词:阿奇霉素 多晶型 差热分析 X-ray衍射法 |
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| Analysis of crystal differences of azithromycin precipitated in ethanol-water mixed solvents |
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| Abstract:Objective To study the crystal differences of azithromycin precipitated in ethanol-water mixed solvents. Methods By differential thermal analysis (DTA), X-ray powder diffraction and C-NMR analysis, the polymorphism of azithromycin were discussed by change the conditions of precipitation to precipitate crystal in ethanol-water mixed solvents. Results 4 kinds of azithromycin isample which had different DTA and XRD characteristics were acquired. Conclusions The DTA and X-ray diffraction characters of azithromycin were obtained, and conditions such as temperature and pressure could expand the research thinking of crystallization. |
| keywords:azithromycin polymorphism DTA XRD |
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