| 西罗莫司的药理学作用研究进展 |
| 投稿时间：2011-02-28 修订日期：2011-06-29 点此下载全文 |
| 引用本文：苏凤云,刘爱军,苏定冯.西罗莫司的药理学作用研究进展[J].药学实践杂志,2011,29(5):336~338,390 |
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| 基金项目:国家自然科学基金资助项目(30901809). |
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| 中文摘要:西罗莫司(sirolimus)又名雷帕霉素(rapamycin)是一种大环内酯抗生素,目前作为免疫抑制剂已在临床上广泛使用。作为国内外研究的热点,研究发现西罗莫司具有抗炎、免疫调节、抗肿瘤、抗动脉粥样硬化、抗衰老和神经保护等多种生物活性。本文综述了其近十多年来西罗莫司药理学作用的研究进展,并对其发展前景做了展望。 |
| 中文关键词:西罗莫司 药理学作用 免疫抑制 神经保护 |
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| Advance in pharmacological effects of sirolimus |
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| Abstract:Sirolimus, a kind of macrolide antibiotics, was widely used in clinical as immunosuppressive agents. In recently research, it had been found that sirolimus had potent biologic activities in terms of anti-inflammatory, immunosuppression, anti-neoplasms, anti-atherosclerosis, anti-aging, neuroprotection and so on. The progress pharmacological effects in the past ten years and forecaesd and the development prospects of sirolimus were reviewed in this paper. |
| keywords:sirolimus pharmacological effect immunosuppression neuroprotection |
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