| 便携式拉曼光谱仪用于降糖药品快速检测的研究 |
| 投稿时间：2010-09-06 修订日期：2010-12-08 点此下载全文 |
| 引用本文：罗娅,柳艳,胡茜茜,陆峰.便携式拉曼光谱仪用于降糖药品快速检测的研究[J].药学实践杂志,2011,29(1):35~37 |
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| 基金项目:国家科技支撑计划重点项目(2008BA155B06). |
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| 中文摘要:目的 考察便携式拉曼光谱仪对降糖类药品的识别能力。 方法 采用TruScan便携式拉曼光谱仪,建立部分降糖药主药成分对照品光谱库,并测定相应制剂的拉曼光谱,然后运用改进的局部直线筛选法计算光谱信息,根据计算结果识别真假药片。 结果 对4种降糖药片(包括阳性样品和阴性样品)和7种常规的辅料(阴性样品)进行识别,灵敏度达到100.00%,专属性达到94.44%,准确度达到96.36%。 结论 本法结合便携式拉曼光谱仪与改进的局部直线筛选法,分析样品具有样品非接触性、非破坏性、时间短、样品所需量小及样品无需制备等优点,可为假药现场判别提供一种新的手段,具有良好的应用前景。 |
| 中文关键词:拉曼光谱法 局部直线筛选法 降糖药 |
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| Fast detection of hypoglycemic drugs by portable Raman spectrometer |
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| Abstract:Objective To investigate the identification capability of portable Raman spectrometer for hypoglycemic drugs. Methods The Raman spectra of the standard substance of active pharmaceutical ingredient of the hypoglycemic drugs and their corresponding preparations were obtained by the TruScan portable Raman spectrometer respectively, followed by the modified Local Straight-Line Screening (LSLS) treatment to decide whether the sample is counterfeited or not. Results Four kinds of hypoglycemic tablets and seven general pharmaceutical excipients were analyzed. The sensitivity, specificity and accuracy reach 100.00%, 94.44% and 96.36%, respectively. Conclusion Combined the portable Raman spectroscopy with the modified Local Straight-Line Screening algorithm, which was non-contact, non-destructive and could rapid analyze the counterfeit drugs on the spot. |
| keywords:Raman spectroscopy Local Straight-Line Screening hypoglycemic drugs |
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