| 作为基因输送载体的壳聚糖衍生物研究进展 |
| 投稿时间：2010-09-20 修订日期：2010-10-21 点此下载全文 |
| 引用本文：李晏.作为基因输送载体的壳聚糖衍生物研究进展[J].药学实践杂志,2011,29(1):8~10,61 |
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| 中文摘要:壳聚糖作为基因载体,目前存在的主要问题是还不能达到足够高的表达效率。其中主要原因是壳聚糖在pH 7.4的生理环境下溶解度较差,壳聚糖与DNA形成的复合物在生理环境下的稳定性较差,缺乏细胞靶向性。本文综述了作为基因输送载体的壳聚糖衍生物研究进展,为进一步研究和开发壳聚糖衍生物提供依据和参考。 |
| 中文关键词:基因载体 壳聚糖 衍生物 |
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| Research progress of chitosan derivatives as gene delivery vector |
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| Abstract:Despite the advantages of chitosan as a non-viral gene delivery vector, the application of this system is significantly limited by its poor solubility (the amino groups on chitosan are only partially protonated at physiological pH 7.4), poor stability of the polyplex at physiological pH, low cell specificity and therefore low transfection efficiency. Chitosan structure modification or additive incorporation is an effective way to improve the stability of the polyplex in biological fluids, enhance targeted cell delivery and facilitate endo-lysosomal release of the complex. In this paper, chitosan derivatives as gene delivery vector were reviewed to facilitate the process of chitosan vector development for clinical application. |
| keywords:gene delivery vector chitosan derivative review |
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