西罗莫司缓释片的制备及其释药因素考察

张晶; 王娟; 宋洪涛; 唐星; 何忠贵

西罗莫司缓释片的制备及其释药因素考察

投稿时间：2009-10-24 修订日期：2009-12-27 点此下载全文

引用本文：张晶,王娟,宋洪涛,唐星,何忠贵.西罗莫司缓释片的制备及其释药因素考察[J].药学实践杂志,2010,28(2):126~129,139

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作者	单位	E-mail
张晶	南京军区福州总医院药学科,福建福州350025	sohoto@vip.so2hu.com.
王娟	南京军区福州总医院药学科,福建福州350025 沈阳药科大学药学院,辽宁沈阳110016
宋洪涛	南京军区福州总医院药学科,福建福州350025
唐星	沈阳药科大学药学院,辽宁沈阳110016
何忠贵	沈阳药科大学药学院,辽宁沈阳110016

基金项目:福建省科技计划项目(2007Y0063)

中文摘要:目的:制备西罗莫司缓释片并对其释药因素进行考察。方法:采用羟丙基甲基纤维素(HPMC)为基本骨架材料制备了西罗莫司凝胶骨架片,对影响释药的因素,如采用羟丙基甲基纤维素(HPMC)规格、用量、填充剂种类、致孔剂用量、压片压力及释放介质等进行了考察。结果:以30%羟丙基甲基纤维素(HPMC K4M)为骨架材料、2%乳糖为致孔剂、微晶纤维素(MCC)为填充剂时,缓释片呈明显一级释放特征。结论:该制剂在体外具有良好的缓释效果,且制备工艺简单易行。

中文关键词:西罗莫司凝胶骨架缓释片体外释放羟丙基甲基纤维素(HPMC)

Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug

Abstract:Objective To prepare the sirolimus sustained-release tablets and study the influence factor.Methods The sirolimus sustained-release tablets were prepared by HPMC as the matrix material.The effects of viscosity of HPMC,sort of an adhensive amount of a lubricant,and the preparation Methods on the release of sirolimus from matrix tablets were observed.Results Based on the Results of single factor tests,an optimal self-prepared matrix sustsained-release tablets which contained 30 % HPMC(K4M),2 % lactose and MCC was definited.The release of the drug was an obvious characteristic in first class.Conclusion The tables have desirable sustain-release property in vitro.The preparation process was simple and can be applied in production.

keywords:sirolimus matrix sustained-release tablets drug release in vitro HPMC

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