| 发形霞水母触手提取物对大鼠离体心脏传导系统的影响 |
| 投稿时间：2010-03-02 修订日期：2010-03-16 点此下载全文 |
| 引用本文：蔡滨欣,郭玉峰,张智,肖良,张黎明.发形霞水母触手提取物对大鼠离体心脏传导系统的影响[J].药学实践杂志,2010,28(2):112~113,125 |
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| 基金项目:全军“十一五”专项项目(06Z020);上海市自然科学基金(06ZR14111) |
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| 中文摘要:目的:观察水母触手提取物(TOE)对大鼠离体心脏传导功能的影响,探讨其心脏毒性可能的作用机制。方法:72只SD雄性大鼠随机分为6组(n=12),利用大鼠离体心脏Langendorff模型,分别给予不同剂量的TOE,观察其对大鼠心脏传导系统的影响。结果:给予TOE后,与空白组比较,心率减慢和心律失常的几率明显增大,并呈现剂量依赖性。结论:TOE对心脏的传导系统具有显著影响,是其心脏毒性的原因之一。 |
| 中文关键词:水母毒素 离体心脏 传导系统 |
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| Effects of tentacle-only extract from jellyfish Cyanea capillata on the conduction system of isolated rat heart |
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| Abstract:Objective To observe the effects of tentacle-only extract(TOE) from Cyanea capillata on the conduction system of isolated rat heart and investigate the mechanism of its cardiac toxicity.Methods Seventy-two Sprague Dawley(SD) rats were randomly divided into six groups(n=12),and Langendorff heart perfusion models were established,then different doses of TOE were applied to each group to observe the effects of TOE on the conduction system of the isolated rat hearts.Results Compared with the control group,all the doses of TOE induced a significant decrease of heart rate,and the incidence of arrhythmia was significantly increased.Moreover,both the effects were dose-dependent.Conclusion The TOE of C.capillata induced significant changes of the conduction system of isolated rat heart,which could partly interpret the mechanism of its cardiac toxicity. |
| keywords:Cyanea capillata tentacle-only extract isolated rat heart conduction system HPMC |
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