| L-2-(N-叔丁氧酰基)-3′,4′-二甲氧基苯丙氨酸乙酯的合成 |
| 投稿时间：2009-04-03 点此下载全文 |
| 引用本文：刘娜,吕加国,周有骏,朱驹.L-2-(N-叔丁氧酰基)-3′,4′-二甲氧基苯丙氨酸乙酯的合成[J].药学实践杂志,2009,27(6):445~447 |
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| 中文摘要:目的:改进L-2-(N-叔丁氧酰基)-3′,4′-二甲氧基苯丙氨酸乙酯的合成工艺。方法:以左旋多巴为起始原料,采用"半分离纯化"的制备方法进行合成,并对处理工艺进行优化。结果:通过此法制备步骤简单,后处理容易,可有效减少原料及中间体的氧化程度。总收率达到45.4%。结论:这是一种易于操作、适合规模化生产的制备工艺。 |
| 中文关键词:左旋多巴 L-2-(N-叔丁氧酰基)-3′,4′-二甲氧基苯丙氨酸乙酯 合成 |
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| An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester |
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| Abstract:Objective:To improve the synthetic process of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester.Methods:The target molecular was prepared from L-DOPA by using a "half-purified" method.The disposition technics were optimized.Results:The synthetic process offers a simple,easy disposal procedure which can effectively reduce the oxidation of raw material and intermediate.The overall yield is 45.4%.Conclusion:The optimized synthetic process is easy to operate and suitable for large-scale production. |
| keywords:L-DOPA L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester synthesis |
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