| 芥子气促进真皮成纤维细胞分泌IL-10的时效和量效研究 |
| 投稿时间：2009-03-18 点此下载全文 |
| 引用本文：田泾,陆坚,杨积顺,胡晋红.芥子气促进真皮成纤维细胞分泌IL-10的时效和量效研究[J].药学实践杂志,2009,27(3):177~178,188 |
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| 基金项目:国家自然科学基金项目资助(30873128) |
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| 中文摘要:目的:探讨芥子气诱导真皮成纤维细胞分泌IL-10的规律。方法:采用ELISA方法,检测不同浓度梯度的芥子气调节IL-10分泌的量效和时效关系。结果:成纤维细胞自身可分泌一定量的IL-10,芥子气作用成纤维细胞后,显著上调IL-10的分泌(P<0.05)。并呈时间依赖性和剂量依赖性。结论:芥子气治疗银屑病的作用机制可能与促进细胞分泌抗炎因子IL-10有关。 |
| 中文关键词:芥子气 真皮成纤维细胞 IL-10 银屑病 |
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| Study on secretion of IL-10 stimulated by sulfur mustard in Human fibroblasts |
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| Abstract:Objective:To explore the rule of secretion of IL-10 stimulated sulfur mustard in human fibroblasts.Methods:The ELISA was used to detect the relationship between dose and efficacy,time course and efficacy of which sulfur mustard adjusted the secretion of IL-10.Results:A portion of IL-10 could be secreted by the human fibroblasts.The secretion of IL-10 could be significantly stimulated after the function of sulfur mustard which depended on the time-course and dosage.Conclusion:The therapeutic mechanism of sulfur mustard to Psoriasis might related with the promotion of the secretion of IL-10. |
| keywords:lovastatin oxidized low density lipoprotein hypoxia inducible factor 1 |
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