| 注射用炎琥宁与头孢呋辛钠配伍的稳定性考察 |
| 投稿时间：2008-08-28 点此下载全文 |
| 引用本文：陈富超,李琴,李鹏,方宝霞,陈琴华,朱军.注射用炎琥宁与头孢呋辛钠配伍的稳定性考察[J].药学实践杂志,2009,27(2):132~133,145 |
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| 中文摘要:目的:考察注射用炎琥宁与注射用头孢呋辛钠在0.9%氯化钠注射液中的配伍稳定性。方法:采用高效液相色谱法,测定注射用炎琥宁与注射用头孢呋辛钠配伍后在室温下8 h内的含量变化,并观察和检测配伍液的外观及pH值变化。结果:配伍液pH值无明显变化,颜色随时间变化逐渐加深,头孢呋辛钠相对百分含量在5 h后降至95%以下,4 h后降解产物峰面积占总峰面积百分比超过1%。结论:注射用炎琥宁与注射用头孢呋辛钠在0.9%氯化钠注射液可配伍使用,但应在4 h内用完。 |
| 中文关键词:高效液相色谱法 炎琥宁 头孢呋辛钠 配伍 稳定性 |
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| Compatible stability of potassium sodium dehydroandrographolide succinate for injection and cefuroxime sodium injection |
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| Abstract:Objective: To study the stability of the mixture of potassium sodium dehydroandrographolide succinate for injection with cefuroxime sodium injection in 0.9% sodium chloride injection.Methods: HPLC method was adopted.The contents were determined after mixing of potassium sodium dehydroandrographolide succinate with Cefuroxime injection in 0.9% sodium chloride injection under the room temperature within 8 hours,and the appearance of the solution was observed and its pH value was determined.Results:No significant differences were found in terms of pH value,but the colour gradually deepens as time goes on.The relative percentage of cefuroxime sodium drops to below 95% after 5 h,and the degradation product peak area accounts for the total peak area percentage to surpass 1% after 4 h.Conclusions:The mixture of potassium sodium dehydroandrographolide succinate with cefuroxime sodium injection in 0.9% sodium chloride injection can be used in NS under room temperature,but must be injected during 4 hours. |
| keywords:HPLC potassium sodium dehydroandrographolide succinate for injection cefuroxime sodium compatibility stability |
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