| 淫羊藿药材HPLC指纹图谱的勾兑研究 |
| 投稿时间：2008-05-04 点此下载全文 |
| 引用本文：王彬,黄河舟,朱臻宇,张海,纪松岗,柴逸峰.淫羊藿药材HPLC指纹图谱的勾兑研究[J].药学实践杂志,2008,(6):432~434,456 |
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| 基金项目:国家“十一五”科技支撑计划课题(2006BAI08B03-07). |
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| 中文摘要:目的:在中药HPLC指纹图谱数据的基础上,对不同来源的中药淫羊藿原药材进行了勾兑研究,寻找提高药材指纹图谱相似度,稳定药材质量的新途径。方法:以道地药材为勾兑目标,药材的夹角余弦相似度为评价指标,使用系统优化的勾兑比例投料进行勾兑实验,采集勾兑药材的HPLC指纹图谱。结果:勾兑后,药材与道地药材的相似度评价结果明显提高,与理论计算的结果一致。结论:相似度差异较大的不同批次中药材通过基于中药指纹图谱的勾兑,相似度评价得到提高,为中药原药材的充分利用提供了新的参考方法。 |
| 中文关键词:勾兑 中药材 淫羊藿 指纹图谱 |
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| Blending of crude Epimedium Brevicornum according to their HPLC fingerprints |
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| Abstract:Objective:To find a new way of improving the quality of TCM,blendings of crude Epimedium Brevicornum from various sources were studied according to their Fingerprints.Methods:Systematic optimization was adopted to determine the mixing ratio of different kinds of non-genuine crude drugs in order to maximize the similarity,which is based on the cosine value between the fingerprints of genuine and non-genuine crude drugs respectively.Fingerprints data were collected after the blending.Results:The similarity of drugs was improved evidently,and it was in accordance with the calculation result.Conclusion:Quality improvement of TCM can be made by blending.Optimized blending of crude drugs might be an efficient method in making full use of the relatively inadequate TCM resources. |
| keywords:blending TCM Epimedium Brevicornum fingerprinting |
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