| 脱氢卡维汀对四氯化碳致小鼠急性肝损伤的保护作用 |
| 投稿时间：2007-08-28 修订日期：2007-09-03 点此下载全文 |
| 引用本文：孙宁玲,汪涛,袁本利,李慧梁,陆国才,张卫东,张川,袁伯俊.脱氢卡维汀对四氯化碳致小鼠急性肝损伤的保护作用[J].药学实践杂志,2008,(1):23~27,50 |
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| 基金项目:国家自然科学基金 |
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| 中文摘要:目的:研究脱氢卡维汀(YHL-DC)对四氯化碳(CCl4)致小鼠急性肝损伤的影响。方法:YHL-DC预防和治疗给药后观察其对CCl4致急性肝损伤小鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)和总胆红素(TBIL)的影响,并对肝脏进行了病理组织学及电镜观察。结果:YHL-DC预防和治疗给药均能显著降低急性肝损伤小鼠ALT、AST和TBIL的升高,有效减轻CCl4引起的小鼠肝细胞变性、坏死、炎性细胞浸润和肝细胞超微结构的破坏。结论:YHL-DC对四氯化碳致小鼠急性肝损伤具有保护作用。 |
| 中文关键词:脱氢卡维汀 岩黄连 四氯化碳 肝损伤 |
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| Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice |
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| Abstract:Objective:To investigate the effects of Dehydrocavidine (YHL-DC) on carbon tetrachloride (CCl4) induced acute liver injury in mice. Methods: The mice were pre-treatment with YHL-DC prior to the administration of CCl4 and post-treatment with YHL-DC after the administration of CCl4, and the changes of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) in these mice were examined respectively. Histopathology changes of liver were also observed under both light and electron microscope. Results: Pre-treatment and post-treatment with YHL-DC significantly prevented increase in serum enzymatic activities of ALT, AST and TBIL in a dose-dependent manner. Hepatocyte degeneration and necrosis, infiltration of inflammatory cells and destruction of hepatocyte ultrastructure appeared in carbon tetrachloride induced acute injured liver in mice, while extenuations were observed in both pre-and post-treatment groups administered with YHL-DC.Conclusion: The results suggest that YHL-DC has a potent hepatoprotective action on CCl4 induced acute liver injury in mice. |
| keywords:Dehydrocavidine corydalis saxicola bunting carbon tetrachloride liver injury |
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