| 液相色谱-质谱联用法检出降糖胶囊中的格列本脲和苯乙双胍 |
| 投稿时间：2007-08-16 点此下载全文 |
| 引用本文：郑成,向智敏.液相色谱-质谱联用法检出降糖胶囊中的格列本脲和苯乙双胍[J].药学实践杂志,2007,(6):388~390 |
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| 中文摘要:目的:建立液相色谱-质谱联用法测定中药中非法掺入的化学降糖药格列本脲和苯乙双胍。方法:以Altima C18色谱柱为固定相,以乙腈-0.1%甲酸溶液(65:35)为流动相,用液相色谱-质谱-质谱法进行定性分析鉴定。结果:在一批降糖胶囊中检测到非法掺入的化学药格列本脲和苯乙双胍。结论:该方法专属性强,灵敏度高,是分析检测中药制剂中添加化学药物的有效方法。 |
| 中文关键词:中药 格列本脲 苯乙双胍 液相色谱-质谱-质谱法 |
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| Detection of gibenclamide and phenformin in Jiangtang capsule by liquid chromatography-electrospray Ionization tandem mass spectrometry |
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| Abstract:Objective:To establish a liquid chromatography-electrospray ionization tandem mass spectrometry(LC-ESI-MS-MS) for the identification of glibenclamide and phenformin illegally added in Jiangtang Capsule.Methods:The detection was performed on Altima C18 column with a mobile phase of acetonitrile-formic acid solution(65-35).The above compounds were identified by LC-MS-MS.Results:Glibenclamide and phenformin were detected illegally added in one sample of Jiangtang capsule.Conclusion:This is an effective method with characteristic and sensitivity for analysis of chemical drugs added in TCM. |
| keywords:traditional Chinese medicine(TCM) glibenclamide phenformin hydrochloride LC-MS-MS |
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