| 非那雄胺的合成 |
| 投稿时间：2006-09-09 点此下载全文 |
| 引用本文：杨艳,马红梅,屈战果,金永生,胡宏岗,吴秋业.非那雄胺的合成[J].药学实践杂志,2007,(5):310~312 |
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| 中文摘要:目的:非那雄胺的合成方法研究。方法:以孕烯醇酮醋酸酯为原料,经次溴酸钠氧化、甲醇甲酯化得到3-羰基-4-雄甾烯-17β-羧酸甲酯,再经Oppenauer氧化、双键的氧化切断、氨解环合、v5双键加氢、1,2位脱氢、Bodroux反应等8步反应制得非那雄胺。结果:总收率36.5%,可大大降低生产成本。结论:此方法原料易得、操作简单、成本低廉、收率高。 |
| 中文关键词:非那雄胺 孕烯醇酮醋酸酯 合成 |
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| Synthesis of finasteride |
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| Abstract:Objective:To study the synthesis of finasteride.Methods: Finasteride was synthesized from pregnenolone acetic ester,and by hypobromous acid oxidation,methanol esterification to give 3-oxo-4-androstene-17β-carboxylic methyl ester.Then by Oppenauer oxidation,cleavage of △4-double bond by oxidation,ring closure by ammonia,hydrogenation of △5-double bond,dehydrogenation of 1,2-position in A-ring and Bodroux reaction to get product.Results:Overall yield was 36.5%.Conclusion:The material of this synthesis is inexpensive,the process is simple,the cost is low and the yield is good. |
| keywords:finasteride pregnenolone acetic ester synthesis |
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