| 甲磺酸地拉韦啶解离常数及分配系数的测定 |
| 投稿时间：2007-04-09 点此下载全文 |
| 引用本文：管清香,林天慕,王恩思.甲磺酸地拉韦啶解离常数及分配系数的测定[J].药学实践杂志,2007,(5):290~291 |
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| 基金项目:吉林省卫生厅重点实验室项目(项目编号:2005055) |
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| 中文摘要:目的:测定甲磺酸地拉韦啶的解离常数和分配系数。方法:采用酸碱滴定法测定不同体积比的甲醇-水溶液中的药物pKa值,再外推至纯水中药物浓度无限稀释时的pKa值。采用HPLC法测定药物的分配系数。结果:甲磺酸地拉韦啶的pKa为4.635,1gP值为2.907。结论:甲磺酸地拉韦啶为弱酸性亲脂性药物。 |
| 中文关键词:甲磺酸地拉韦啶 解离常数 分配系数 酸碱滴定法 |
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| Determination of the dissociation constant and partition coefficient of mesylate delavirdine |
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| Abstract:Objective: To determine the dissociation constant and partition coefficient of mesylate delavirdine.Methods:The dissociation constant was determined with acid-base titration method in methanol /water solutions with different ratios,the value to infinite diluted in pure water was extrapolated and the partition coefficient was determined with bottle-shaking method by HPLC.Results: The pKa and 1gP of mesylate delavirdine in n-octyl alcohol were 4.635 and 2.907 respectively.Conclusions: mesylate delavirdine is a weak acid with lipophilic property. |
| keywords:mesylate delavirdine ionization constant partition coefficient acid-base titration. |
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