| 单硝酸异山梨酯口腔崩解片的制备及药剂学研究 |
| 投稿时间：2006-11-22 点此下载全文 |
| 引用本文：赵楠,汤真,王艳萍,薛万俐.单硝酸异山梨酯口腔崩解片的制备及药剂学研究[J].药学实践杂志,2007,(2):94~97 |
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| 中文摘要:目的:筛选单硝酸异山梨酯口腔崩解片的处方并考察片剂质量。方法:采用正交设计法筛选片剂处方,用HPLC法测定片剂的含量。结果:所得的优化处方为:MCC与L-HPC的比例为8:2(32%,8%),CC-Na为3%,甘露醇为15%,乳糖为31%。所得的片剂在20 s内完全崩解,1 min释药80%以上,口感良好。结论:选择合适的辅料,可以生产出崩解快、口感好,能够快速起效的口腔崩解片。 |
| 中文关键词:单硝酸异山梨酯 口腔崩解片 正交设计 |
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| Preparation and study of pharmaceutics of 5-ISMN orally disintegrating tablets |
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| Abstract:Objective:To optimize the formulation of 5-ISMN orally disintegrating tablets,and inspect quality of prepared tablets. Methods:The orthogonal design was used and HPLC was used to determine the concentration.Results:Besides 5-ISMN,the tablets were composed of croscarmellose sodium 3%,mannite 15%,lactose 31%,MCC/L-HPC ratio was 8:2(32%,8%).The prepared tablets disintegrated completely in 20s,dissolved more than 80% in 2min and tasty fine.Conclusion:Choose properly excipients,we can produce orally rapidly-disintegrating tablets of rapidly disintegrating,tasty well and rapid absorption. |
| keywords:5-ISMN orally disintegrating tablet orthogonal design |
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