| 糙叶败酱中环烯醚萜苷元成分抗结肠癌作用的实验研究 |
| 投稿时间：2006-03-20 点此下载全文 |
| 引用本文：毛俊琴,李铁军,邱彦,芮耀诚,顾正兵.糙叶败酱中环烯醚萜苷元成分抗结肠癌作用的实验研究[J].药学实践杂志,2007,(1):12~15 |
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| 基金项目:上海-SK研究与发展基金(2004006-t) |
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| 中文摘要:目的:研究糙叶败酱中环烯醚萜苷元成分体外抗小鼠结肠癌细胞株C26作用和对小鼠结肠癌(C26)移植性肿瘤的作用。方法:采用四唑盐(MTT)比色法研究糙叶败酱中环烯醚萜苷元PS-Ⅰ和BJ3401对小鼠结肠癌细胞株C26生长的影响;于F1小鼠皮下注射小鼠结肠癌细胞株(C26)建立小鼠结肠癌移植性肿瘤模型,观察糙叶败酱中总环烯醚萜苷元对结肠癌移植性肿瘤小鼠的影响。结果:环烯醚萜苷元PS-Ⅰ、BJ3401可显著抑制小鼠结肠癌细胞株C26的生长,并且具有一定的剂量依赖关系;总环烯醚萜苷元可显著减轻荷瘤鼠瘤重。结论:糙叶败酱中环烯醚萜苷元具有抗结肠癌的作用。 |
| 中文关键词:糙叶败酱 抗肿瘤 环烯醚萜苷元 人结肠癌细胞株C26 |
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| Effects of the iridoid aglycones from Patrinia scabra on colon cancer |
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| Abstract:Objective:To study the effects of the iridoid aglycones from Patrinia scabra on mouse colon cancer cell line C26 in vitro and on transplanting-tumor of mouse colon cancer cell C26.Methods:The effects of the iridoid aglycones from Patrinia scabra(PS-I, BJ3401)on mouse colon cancer cell line C26 were studied by MTF experiment,the transplanting-tumor model of mouse colon cancer was established by hypodermic inoculating the mouse colon cancer cell lines C26 into the FI mice.Results:The iridoid aglycones PS -I and BJ3401 could significantly inhibit proliferation of C26 cell line in a doge-dependent manner,gross iridoid aglycones could sig- nificantly lessen the weight of the transplanting-tumor in mice.Conclusion :The iridoid aglycones from Patrinia scabra have anti-colon carcinoma activity. |
| keywords:Patrinia scabra the iridoid aglycones mouse colon cancer line C26 transplanting-tumor |
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