| 国产加替沙星与左氧氟沙星双盲随机对照治疗细菌感染的Meta分析 |
| 投稿时间：2006-06-14 点此下载全文 |
| 引用本文：张美和,黄成华,丁晓虎,沈晓琴,韩竹俊.国产加替沙星与左氧氟沙星双盲随机对照治疗细菌感染的Meta分析[J].药学实践杂志,2006,(6):346~351 |
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| 中文摘要:目的：探讨国产加替沙星治疗细菌感染的有效性和安全性。方法：按照系统评价的要求全面检索了中国数字医院图书馆(www．chkd．cnki．net)、中国医学科学院的中国生物医学文献光盘数据库(CBM disk),对符合纳入标准的18篇文献共计2253名患者进行了Meta分析。结果：国产加替沙星组临床有效率与左氧氟沙星组临床有效率OR合并值1．42(95%CI为1．03～1．98),Z=2．11,P=0．03,差异有显著性；痊愈率、细菌清除率和不良反应发生率没有显著差异。结论：国产加替沙星治疗细菌感染的有效率比左氧氟沙星高。 |
| 中文关键词:加替沙星 左氧氟沙星 双盲随机对照 细菌感染 Meta分析 |
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| A meta-analysis of treatment of bacterial infections with double-blind randomized clinical study of indigenous gatifloxcin versus levofloxacin |
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| Abstract:Objective:To estimate the efficacy and safety of indigenous gatifloxacin and levofloxacin on bacterial infection.Methods:According to the requirements of Cochrane systematic review,a thorough literature search was performed among Chinese digital Hospital Library(www.chkd.cnki.net) and Chinese Biomedical Literature Disk Database(CBM disk).A meta analysis was per- formed on a total of 2 253 patients involved in 18 papers which met the inclusion criteria.Results:The clinical effective rate of indige- nous gatifloxacin treatment group versus levofloxacin treatment group was found between the two groups( OR 1.42,95% CI 1.03～1.98,Z=2.11 P=0.03) have significant difference.Clinical cure rates、corresponding bacterial eradication rates and adverse reac- tion rates have no significant difference.Conclusions:Indigenous gatifloxacin treatment bacterial infection effectivenessis higher than levofloxacin. |
| keywords:gastifloxacin levofloxacin double-blind randomized bacterial infections meta-analysis |
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