| 云南狗牙花总碱的镇痛作用 |
| 投稿时间：2006-01-16 点此下载全文 |
| 引用本文：陈梅玉,周丽华,张晓冬,罗新根,陈海生,黄矛.云南狗牙花总碱的镇痛作用[J].药学实践杂志,2006,(4):203~205 |
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| 基金项目:国家自然科学基金资助项目(NO.20272081) |
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| 中文摘要:目的:研究云南狗牙花总碱(total Ervatamia yuunansis alkaloid,TEYA)对小鼠的镇痛作用。方法:采用小鼠热板法,观察TEYA的镇痛作用及对吗啡的镇痛作用的影响。结果:与同期对照组相比,TEYA的3个剂量组均可显著提高小鼠的病阈值,镇痛效果随剂量的增加呈剂量依赖关系;同时给予TEYA(10、20mg／kg)和吗啡4mg／kg,有协同镇痛的作用;纳洛酮4mg／kg可以部分拮抗TEYA的镇痛作用。结论:TEYA有明显的镇痛作用,其作用可能部分通过阿片受体来实现。 |
| 中文关键词:云南狗牙花总碱 镇痛作用 小鼠 |
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| Antinociceptive effects of total Ervatamia yunnansis alkaloid in mice |
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| Abstract:Objective:To observe the antinoeiceptive effect of total Ervatamia yunnansis alkaloid(TEYA) in mice. Methods:The mice hot-plate antinociceptve test was used to study the analgesic effects of TEYA and the effect on morphine in mice. Results:The three groups with different dosage of TEYA could significantly increase the pain threshold in mice and the effects increased in a dose-related manner. TEYA(10、20 mg/kg) combined with morphine 4 mg/kg had a synergic analgesic effect. The analgesic effect of TEYA could he partly blocked by naloxone 4 mg/kg. There were significantly differences between administration group and control group in the hot-plate test. Conclusion:TEYA has significant antinoeiceptive activity in hot-plate lest in mice which may be mediated by way of opioid receptors. |
| keywords:total Ervatamia yunnansis alkaloid analgesia mice |
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