| HPLC法测定灰指灵药膏中间苯二酚、水杨酸、苯甲酸的含量 |
| 投稿时间：2003-11-22 点此下载全文 |
| 引用本文：傅承清,张晋云.HPLC法测定灰指灵药膏中间苯二酚、水杨酸、苯甲酸的含量[J].药学实践杂志,2004,(6):357 |
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| 中文摘要:目的 建立灰指灵药膏中间苯二酚、水杨酸、苯甲酸的含量测定方法。方法 采用高效液相色谱法,以C18为固定相,甲醇-磷酸二氢钠(40:60)为流动相,测定波长为254nm。结果 间苯二酚、水杨酸、苯甲酸分别在40.0～200.0μg/mL范围内,其峰面积值与浓度具有良好的线性关系(r=0.9999、0.9997、0.9999),平均回收率分别为98.1%、97.9%、97.7%。RSD分别为1.88%、1.82%、1.46%。结论 该方法可靠,精密度高,可作为该制剂的质量控制方法。 |
| 中文关键词:高效液相色谱法 灰指灵药膏 含量测定 |
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| Determination of resorcinol, salicylic acid, benzoic acid in hueizhilin ointment by high-performance liquid chromatography |
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| Abstract:Objective To establish a method of determination of contents in Hueizhilin ointment. Methods HPLC was used with C18 column as stationary phase and methanol-sodium dihydrogen phosphate (40:60) as mobile phase.The detection wavelength was 254nm.Results The calibration curve is linear between 40.0～200.0μg/mL of resorcinol salicylic acid and benzoic acid.The average recorery was 98.1%, 97.9%,97.7% with RSD of 1.88%,1.82%,1.46%.Conclusion The method is reliable, accurate and can be used for the determination of the contents of Hueizhilin ointment. |
| keywords:high-performance liquid chromatography Hueizhilin ointment determination of content |
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