| 非水酸碱电位滴定法测定阿德福韦酯原料药含量 |
| 投稿时间：2003-10-11 点此下载全文 |
| 引用本文：蒋晔,徐智儒,田孟军.非水酸碱电位滴定法测定阿德福韦酯原料药含量[J].药学实践杂志,2004,(5):291~293 |
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| 中文摘要:目的 建立测定阿德福韦酯原料药含量的非水酸碱电位滴定方法。方法 以无水冰醋酸-醋酐(1:3)作为溶剂,以高氯酸标准溶液(0.1 mol/L)为滴定剂进行非水电位滴定。结果 阿德福韦酯原料药平均含量为99.7%,RSD为0.2%。结论 本方法准确,重现性好,适用于阿德福韦酯原料药的质量控制。 |
| 中文关键词:非水酸碱电位滴定法 含量 阿德福韦酯 |
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| Determination of the adefovir dipivoxil raw material by nonaqueous acid-base e-lectrolytic titrations |
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| Abstract:Objective To establish nonaqueous acicle-base electrolytic titrations method for the determination of adefovir dipivoxil raw material, and investigate the infulents of the proportion of acetic anhydride in the acetric anhydride and anhydro-glacial acetic acid mixed solution. Methods 75% acetric anhydride was selected as the solvent, and 0.1 mol/L perchloric was selected as the standard solution to determine the content of adefovir dipivoxil in raw material. Results It was found that the end point was changed more acuate with the increasing of acetric anhydride proportion in solvent. The average recovery of adefovir dipivoxil raw material was 99.7% and RSD was 0.2%. Conclusion The method was simple, accurate, and is suitable for the quality control of adefovir dipivoxil raw material. |
| keywords:nonaqueous acid-base electrolytic titrations content adefovir dipivoxil |
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