HPLC法测定复方草玉梅含片中甘草酸的含量

陈万里; 史蕙; 任渝江

HPLC法测定复方草玉梅含片中甘草酸的含量

投稿时间：2003-08-25 点此下载全文

引用本文：陈万里,史蕙,任渝江.HPLC法测定复方草玉梅含片中甘草酸的含量[J].药学实践杂志,2004,(2):85~87

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作者	单位
陈万里	贵州省药品检验所, 贵州贵阳 550004
史蕙	贵州省药品检验所, 贵州贵阳 550004
任渝江	中国人民解放军第44医院, 贵州贵阳 550009

中文摘要:目的建立复方草玉梅含片的含量测定方法。方法采用高效液相色谱法,反相C₁₈柱,以甲醇-0.2mol/L醋酸铵溶液-冰醋酸(53:47:1)为流动相,流速:1.0mL/min;检测波长250nm。结果甘草酸单铵盐在0.0520. 468mg/mL范围内具有良好的线性关系,r=0.9996,精密度及回收率结果良好。结论本法简单,方便,线性关系和重现性好,可有效地对本品进行质量控制。

中文关键词:复方草玉梅含片甘草酸 HPLC

Determination of the glycyrrhizic acid in compound anemone rivularis buccal tablets by HPLC

Abstract:Objective To establish a method to determine the Glycyrrhizic acid in Compound Anemone rivularis tablets. Methods Using HPLC with C₁₈ column and mobile phase of methanol-0.2mol/L ammonium acetate solution-glacial acetic acid(53:47:1) with flow rate of 1.0 mL/min, the detection wavelength was 250nm. Result The linear range was 0.0520. 468mg/mL for ammonium glycyrrhizinate (r=0.9996), good linearity, precision and recovery were obtained. Conclusion The method is simple, rapid and accurate and could be used for quality control of compound anemone rivularis tablets.

keywords:compound anemone rivularis tablets glycyrrhizic acid HPLC

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