| 噻唑烷二酮类药物与胰岛素抵抗 |
| 投稿时间：2003-11-20 点此下载全文 |
| 引用本文：白红艳,邹文俊,张焱.噻唑烷二酮类药物与胰岛素抵抗[J].药学实践杂志,2004,(2):65~67 |
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| 中文摘要:目的 综述噻唑烷二酮类(TZDS)药物治疗胰岛素抵抗的作用机制、在Ⅱ型糖尿病中的作用、对胰岛素敏感性的影响、副作用和临床使用。方法 文献学方法。结果 噻唑烷二酮类(TZDS)药物通过多种机制提高了胰岛素抵抗及Ⅱ型糖尿病病人对胰岛素的敏感性,改善了患者的胰岛素抵抗状态。结论 噻唑烷二酮类(TZDS)药物具有很高的临床使用价值,但使用时应注意其所带来的不良反应。 |
| 中文关键词:噻唑烷二酮类(TZDS)药物 胰岛素抵抗 Ⅱ型糖尿病 副作用 |
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| Thioazolidinediones and insulin resistance |
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| Abstract:Objective To review the mechanisms of action of thiazolidinediones, clinical efficacy in patients with type 2 diabetes mellitus, effects on insulin sensitivity, side-effects and guideline for the clinical use of thiazolidinediones. Methods Analyze the correlated literature at home and abroad. Results Thiazolidinediones improve insulin sensitivity of patients with insulin resistance and type 2 diabetes mellitus through several mechanisms. Conclusion Thiazolidinediones are very valuable in clinic, but patient should pay attention to their adverse effects. |
| keywords:thiazolidinediones insulin resistance type 2 diabetes mellitus adverse effects |
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