| HPLC同时测定感冒通中的双氯芬酸钠和马来酸氯苯那敏的含量 |
| 投稿时间：2002-09-20 点此下载全文 |
| 引用本文：祝志贤,梁秋文,丘民新.HPLC同时测定感冒通中的双氯芬酸钠和马来酸氯苯那敏的含量[J].药学实践杂志,2002,(6):346~348 |
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| 中文摘要:目的 建立同时检测感冒通片中的双氯芬酸钠和马来酸氯苯那敏的高效液相法。方法 用反相高效液色谱法,在C18柱上,采用梯度洗脱,紫外检测波长为264nm,可同时检测感冒通片中的双氯芬酸钠和马来酸氯苯那敏。结果 该方法简便、准确、两组分的线性关系良好,回收率(n=6):双氯芬酸钠100.89%,RSD0.58%;马来酸氯苯那敏99.04%,RSD0.74%。结论 本方法能有效地使马来酸氯苯那敏与溶剂峰完全分离,最适合作为溶出度或释放度的含量测定。 |
| 中文关键词:高效液相色谱法 感冒通 双氯芬酸钠 马来酸氯苯那敏 |
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| Simultaneously determination of diclofenac sodium and chlorphenamine maleate by HPLC |
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| Abstract:OBJECTIVE To establish a HPLC method for simultaneously determination of diclofenac sodium and chlorphenamine maleate. METHODS The content of the Ganmaotong was determined by reverse HPLC using UV detector at wavelength of 264nm. RESULTS The method was linear over the ranger of 0.024～0.24mg·ml-1(diclofenac sodium) and 0.004～0.04mg·ml-1(chlorphenamine maleate). The mean recovery was 100.89% and 99.04%, RSD,0.58% and 0.74%. CONCLUSION The method was simple rapid and precise. It was suitable for quantitative analysis of the Ganmaotong tablet. |
| keywords:HPLC Ganmaotong tablet diclofenac sodium chlorphenamin maleate |
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