| 利巴韦林片的处方优化 |
| 投稿时间：2001-02-12 点此下载全文 |
| 引用本文：危华玲,卢文胜.利巴韦林片的处方优化[J].药学实践杂志,2002,(2):88~90 |
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| 中文摘要:目的 筛选利巴韦林片的最佳处方。方法 考察糊精、羧甲基淀粉钠、微晶纤维素和低取代羟丙基纤维素对利巴韦林片的质量影响。结果 所筛选的适宜润湿剂为 75%乙醇,L-HPC和微晶纤维素的最佳用量分别为 10%和 15%.按照最佳处方制备的利巴韦林片硬度和外观大为改善。结论 本法处方合理,工艺简单,所制备的利巴韦林片适合临床应用。 |
| 中文关键词:利巴韦林片 处方优化 正交试验 |
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| Prescription optimize of ribavirini tablets |
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| Abstract:OBJECTIVE To obtain the optimum prescription of ribavirini tablets METHODS The effect of dextrin CMS-Na microcrystalline cellulose and L-HPC on the quality of ribavirini tablets were studied RESULTS The optimum mistening agents is 75% alcohol,and the optimum amount of L-HPC and micro-crystaline cellulose are 10% and 15% respectively Ribavirini tablets prepared with this optimum prescription was much better in terms of hardness and surfaces CONCLUSION The method is reasonable,and the ribavirini tablets were suitable for clinical use. |
| keywords:ribavirin tablet prescription optimize orthogonal experiment design |
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