| 重组人表皮生长因子凝胶剂的研制 |
| 投稿时间：2000-11-29 点此下载全文 |
| 引用本文：陆兵,谢英华,程度胜,朱厚础.重组人表皮生长因子凝胶剂的研制[J].药学实践杂志,2001,(3):143~145 |
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| 中文摘要:目的 研制用于创伤修复的重组人表皮生长因子(recombinant hum an epidermal growth factor, rhEGF)凝胶剂。方法 以卡泊姆为水溶性凝胶基质制备rhEGF的凝胶剂,并以大鼠皮肤急性创伤模型和大鼠皮肤烫伤模型评价了rhEGF凝胶剂在创伤修复中的效果。结果 所得rhEGF凝胶剂制备工艺简单、质量可靠、使用方便,对于大鼠皮肤急性创伤和大鼠皮肤烫伤具有明显的疗效。结论 rbEGF凝胶剂可望应用于临床。 |
| 中文关键词:表皮生长因子 卡泊姆 凝胶剂 创伤修复 |
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| Development of recombinant human epidermal growth factor gels |
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| Abstract:OBJECTIVE To develop recombinant human epidermal growth factor (rhEGF) gels for external application to wound healing.METHODS Carbopol was used as water soluable matrix to prepare rhEGF gels.The wound healing effects of rhEGF were evaluated in acute traumatic rats and scalded rats.RESULTS rhEGF gels could be manuf actured easily w it h reliable quality.They could also be applied conveniently to accelerate wound healing in acute traumatic rats and scalded rats.CONCLUSION Such rhEGF gels could be developed for the clinical application. |
| keywords:recombinant human epidermal growth factor carbomer gels wound healing |
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